Click‐and‐Bond: Room‐Temperature and Solvent‐Free Bonding of Polymer‐Based Microfluidic Devices

The production of a new class microfluidic devices built from thermoplastic materials has recently aroused interest in high-volume and cost-effective fabrication sensing devices. During device formation, the bonding two slides, one containing microchannels another used as non-modified capping layer, is generally performed at high temperature, pressure, and/or employing organic solvents. Such procedures, however, are not compatible with use slides pre-functionalized biomolecules. Here low-temperature, UV-light-free, solvent-free method for polymeric devices, based on poly-l-lysine (PLL) polymers modified click-chemistry moieties presented. advantages obtained PLL appended complementary groups enable fast adsorption onto substrates room followed by stable between complementarily functionalized under mild conditions. Bonded fluidic show resistance to fluid pressures well above those needed practical application. optimal density (2–5%) reactive assessed using lap shear tests. here developed achieves low which promises biomolecules prior sealing process, applicable wide range materials.